Journal article
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of sphingosine kinase
N Etemadi, M Chopin, H Anderton, MC Tanzer, JA Rickard, W Abeysekera, C Hall, SK Spall, B Wang, Y Xiong, T Hla, SM Pitson, CS Bonder, WWL Wong, M Ernst, GK Smyth, DL Vaux, SL Nutt, U Nachbur, J Silke
Elife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2015
DOI: 10.7554/eLife.10592
Abstract
TRAF2 is a component of TNF superfamily signalling complexes and plays an essential role in the regulation and homeostasis of immune cells. TRAF2 deficient mice die around birth, therefore its role in adult tissues is not well-explored. Furthermore, the role of the TRAF2 RING is controversial. It has been claimed that the atypical TRAF2 RING cannot function as a ubiquitin E3 ligase but counterclaimed that TRAF2 RING requires a co-factor, sphingosine-1-phosphate, that is generated by the enzyme sphingosine kinase 1, to function as an E3 ligase. Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-κB and MAP kinase signalling and caused epidermal hyperpl..
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Awarded by National Cancer Institute
Funding Acknowledgements
[ "Victorian State Government Operational Infrastructure Support Nima Etemadi Michael Chopin Holly Anderton Maria C Tanzer James A Rickard Waruni Abeysekera Cathrine Hall Sukhdeep K Spall Gordon K Smyth David L Vaux Stephen L Nutt Ueli Nachbur John Silke ..................", "Independent Research Institutes Infrastructure Support 361646 Nima Etemadi Michael Chopin Holly Anderton Maria C Tanzer James A Rickard Waruni Abeysekra Cathrine Hall Sukhdeep K Spall Gordon K Smyth David L Vaux Stephen L Nutt Ueli Nachbur John Silke", "Thomas William Francis and Violet Coles Trust Fund James A Rickard John Silke", "National Health and Medical Research Council 546272 Bing Wang", "National Institutes of Health HL67330 Yuquan Xiong Timothy Hla", "National Institutes of Health CA77839 TH Yuquan Xiong Timothy Hla", "Swiss National Science Foundation 310030- 138085 Wendy Wei-Lynn Wong", "National Health and Medical Research Council 1048278 Stephen L Nutt", "National Health and Medical Research Council 1058238 Stephen L Nutt", "Swiss National Science Foundation PA00P3_ 126249 Ueli Nachbur", "National Health and Medical Research Council 1058190 John Silke", "National Health and Medical Research Council 541901 John Silke", "National Health and Medical Research Council 1025594 John Silke", "National Health and Medical Research Council 1046984 John Silke", "The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication." ]